oligo-MyD88:Mal:activated TLR IRAK4:oligo-MyD88:Mal:activated TLR IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex Authored: de Bono, B, 2005-08-16 10:54:15 Edited: Shamovsky, V, 2012-11-06 IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll receptor signaling - any interference with IRAK-4's kinase activity virtually abolishes downstream events. This is not the case with other members of the IRAK family [Suzuki N et al 2002; Li S et al 2002]. Pubmed11960013 Pubmed12297423 Pubmed18829464 Pubmed19498957 Pubmed19592493 Pubmed20485341 Reactome Database ID Release 43166082 Reactome, http://www.reactome.org ReactomeREACT_6975 Reviewed: Gay, NJ, 2006-04-24 16:48:17 Reviewed: Gillespie, ME, 2010-11-30 Reviewed: Napetschnig, Johanna, 2012-11-16 has a Stoichiometric coefficient of 4