MAL:PI(4,5)P2 MAL(TIRAP) binds PIP2-rich regions in the plasma membrane Authored: Shamovsky, V, 2012-05-15 Edited: Shamovsky, V, 2012-11-19 Pubmed11544529 Pubmed15585605 Pubmed16751103 Pubmed19509286 Reactome Database ID Release 432559456 Reactome, http://www.reactome.org ReactomeREACT_150399 Reviewed: Granucci, Francesca, Zanoni, Ivan, 2012-11-13 Upon LPS stimulation, Mal(TIRAP) was shown to bind to PIP2-rich regions on the cell surface trough its phosphatidylinositol 4,5-bisphosphate-binding domain [Kagan JC and Medzithov R 2007]. TLR2 or 4 associates with Mal(TIRAP) on the cell surface, which in turn facilitates the binding of MyD88 to the activated TLR, leading to NF-kB and MAPK activation [Nunez Miguel R et al 2007, Nagpal K et al 2009].