IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation Authored: Shamovsky, V, 2010-08-25 Edited: Shamovsky, V, 2010-11-15 Pubmed15361868 Pubmed15492225 Pubmed15767370 Reactome Database ID Release 43975188 Reactome, http://www.reactome.org ReactomeREACT_25312 Reviewed: Gillespie, ME, 2010-10-29 Upon TLR7/8 or 9 stimulation IRF7, but not IRF3, forms a signaling complex with MyD88, TRAF6[Honda K et al 2004, Kawai T et al 2004], IRAK1 [Uematsu S et al 2005], Also IRAK4 was shown to mediate IRF7 activation[Honda K et al 2004]. has a Stoichiometric coefficient of 4