p-Pellino-1,2,(3) TRAF6:hp-IRAK1:Pellino TRAF6:hp-IRAK1 Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation Authored: Shamovsky, V, 2010-06-01 Edited: Shamovsky, V, 2010-11-15 Pellino isoforms -1, 2 and 3 have been shown to interact with IRAK1 and IRAK4 (Jiang et al. 2003, Strellow et al. 2003, Butler et al. 2005, 2007). It has been also reported that Pellino-1 forms a complex with TRAF6, but not TAK1 or IL1R (Jiang et al. 2003), suggesting that Pellino-1 function as intermediate complex with IRAK1 in the propagation of signal from the activated receptor to activation of TAK1. <p>All Pellino isoforms function as E3 ubiquitin ligases in conjunction with several different E2-conjugating enzymes - Ubc13-Uev1a, UbcH4, or UbcH5a/5b.(Schauvliege R et al. 2006, Butler MP et al. 2007, Ordureau A et al. 2008). Their C-terminus contains a RING-like domain which is responsible for IL1-induced Lys63-linked polyubiquitination of IRAK1 in vitro. Pubmed12496252 Pubmed12860405 Pubmed15917247 Pubmed16884718 Pubmed17675297 Pubmed17997719 Pubmed18326498 Pubmed19022706 Reactome Database ID Release 43975142 Reactome, http://www.reactome.org ReactomeREACT_25023 Reviewed: Gillespie, ME, 2010-10-29