TRAF6:hp-IRAK1:Pellino p-Pellino:hp-IRAK1:TRAF6 IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation Authored: Shamovsky, V, 2010-06-01 Both IRAK1 and IRAK4 were shown to phosphorylate Pellino isoforms in vitro. The phosphorylation of Pellino proteins is a necessary step in enhancing of their E3 ubiquitin ligase activity. It remains unclear whether IRAK1(as shown here), IRAK4, or both protein kinases mediate the activation of Pellino isoforms in vivo. Edited: Shamovsky, V, 2010-11-15 Pubmed17675297 Pubmed17997719 Pubmed19264966 Reactome Database ID Release 43975139 Reactome, http://www.reactome.org ReactomeREACT_25241 Reviewed: Gillespie, ME, 2010-10-29