IKK complex TRAF6:K63-linked polyUb p-IRAK1:IKK complex K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. Authored: Shamovsky, V, 2010-06-01 Edited: Shamovsky, V, 2010-11-15 NF-kappa-B essential modulator (NEMO, also known as IKKG abbreviated from Inhibitor of nuclear factor kappa-B kinase subunit gamma) is the regulatory subunit of the IKK complex which phosphorylates inhibitors of NF-kappa-B leading to dissociation of the inhibitor/NF-kappa-B complex. NEMO binds to K63-pUb chains (Ea et al. 2006; Wu et al. 2006), linking K63-pUb-hp-IRAK1 with the IKK complex. Models of IL-1R dependent activation of NF-kappaB suggest that the polyubiquitination of both TRAF6 and IRAK1 within a TRAF6:IRAK1 complex and their subsequent interactions with the TAK1 complex and IKK complex respectively brings these complexes into proximity, facilitating the TAK1-catalyzed activation of IKK (Moynagh, 2008). Pubmed16547522 Pubmed16603398 Pubmed18180283 Pubmed18347055 Pubmed19022706 Reactome Database ID Release 43975119 Reactome, http://www.reactome.org ReactomeREACT_25072 Reviewed: Gillespie, ME, 2010-10-29