MyD88 complexed with the activated TLR receptor oligo-MyD88:activated TLR7-9 MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 Authored: Shamovsky, V, 2010-09-22 Edited: Shamovsky, V, 2010-11-15 Pubmed19592493 Pubmed20485341 Pubmed20966070 Reactome Database ID Release 43975098 Reactome, http://www.reactome.org ReactomeREACT_25392 Reviewed: Gillespie, ME, 2010-10-29 Structural analysis of MyD88:IRAK4 and MyD88:IRAK4:IRAK2 suggested that upon MyD88 recruitment to an activated dimerized TLR the MyD88 death domains clustering induces the formation of Mydosome, a large oligomeric signaling platform (Motshwene PG et al 2009, Lin SC et al 2010). Assembly of these Myddosome complexes brings the kinase domains of IRAKs into proximity for phosphorylation and activation. The oligomer complex stoichiometry was reported as 7:4 and 8:4 for MyD88:IRAK4 (Motshwene PG et al 2009), and 6:4:4 in the complex of MyD88:IRAK4:IRAK2(Lin SC et al 2010). has a Stoichiometric coefficient of 4