oligo-MyD88:activated TLR7-9 IRAK4:oligo-MyD88:activated TLR 7/8 or 9 IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex Authored: Shamovsky, V, 2010-08-25 Edited: Shamovsky, V, 2010-11-15 IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll receptor signaling - any interference with IRAK-4's kinase activity virtually abolishes downstream events. This is not the case with other members of the IRAK family [Suzuki N et al 2002; Li S et al 2002]. Pubmed11960013 Pubmed12297423 Pubmed16286015 Pubmed18794297 Reactome Database ID Release 43975156 Reactome, http://www.reactome.org ReactomeREACT_24953 Reviewed: Gillespie, ME, 2010-10-29 has a Stoichiometric coefficient of 4