TRIF:activated TLR3/TLR4 RIP1:TRIF:activated TLR3/TLR4 TRIF:activated TLR3/TLR4 complex recruits RIP1 Authored: de Bono, B, 2005-08-16 10:54:15 Edited: Shamovsky, V, 2011-08-12 Pubmed15064760 Pubmed15814722 Pubmed16115877 Pubmed16246838 Pubmed21931591 RIP1 is recruited to the activated TLR receptor by binding to TICAM1(TRIF) via its RHIM motif, followed by its polyubiquitination. Polyubiquitination is possibly mediated by TRAF6 that is also recruited to the TICAM1 [Cusson-Hermance N et al 2005]. Other E3-ubiquitin ligases - cIAP1 and cIAP2 - have been reported to promote polyubiquitination of RIP proteins [Bertrand MJM et al 2011].<p> RIP3 was shown to inhibit TRIF-induced NF-kB activation in dose-dependent manner when overexpressed in HEK293T cells by competing with TRIF to bind RIP1 [Meylan E et al 2004]. Reactome Database ID Release 43168921 Reactome, http://www.reactome.org ReactomeREACT_6713 Reviewed: Fitzgerald, Katherine A, 2012-11-13 Reviewed: Gay, NJ, 2006-04-24 16:48:17 Reviewed: Gillespie, ME, 2010-11-30 has a Stoichiometric coefficient of 2