viral dsRNA :TLR3 Viral dsRNA (-) Stranded Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) Authored: Luo, F, 2005-11-10 11:23:18 Edited: Shamovsky, V, 2012-02-19 Pubmed11607032 Pubmed18420935 Reactome Database ID Release 43168092 Reactome, http://www.reactome.org ReactomeREACT_6753 Reviewed: Gay, NJ, 2006-04-24 16:48:17 Viral dsRNA triggers an antiviral pathway mediated by toll like receptor 3. TLR3 dimerization occurs upon ligand binding to positivly charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA. has a Stoichiometric coefficient of 2