IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR Authored: Shamovsky, V, 2010-10-06 Edited: Shamovsky, V, 2011-08-12 First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1. Pubmed11960013 Pubmed14625308 Reactome Database ID Release 43975878 Reactome, http://www.reactome.org ReactomeREACT_27228 Reviewed: Gillespie, ME, 2011-02-10 Reviewed: Li, L, 2011-08-04 has a Stoichiometric coefficient of 4