MIR26A microRNAs bind PTEN mRNA Authored: Orlic-Milacic, M, 2012-07-18 Edited: Matthews, L, 2012-08-03 MIR26A microRNAs, miR-26A1 and miR-26A2, transcribed from genes on chromosome 3 and 12, respectively, bind PTEN mRNA (Huse et al. 2009).<br><br> The MIR26A2 locus is frequently amplified in glioma tumors that retained one wild-type PTEN allele. The resulting miR-26A2 overexpression leads to downregulation of PTEN protein level. Overexpression of miR-26A2 was shown to enhance tumorigenesis and prevent loss of heterozigosity at the PTEN locus in a mouse PTEN +/- glioma model, based on a monoallelic PTEN loss (Huse et al. 2009, Kim et al. 2010). Pubmed19487573 Pubmed20080666 Reactome Database ID Release 432318752 Reactome, http://www.reactome.org ReactomeREACT_147761 Reviewed: Thorpe, Lauren, 2012-08-13 Reviewed: Yuzugullu, Haluk, 2012-08-13 Reviewed: Zhao, Jean J, 2012-08-13 miR-26A RISC PTEN mRNA:miR-26A RISC PTEN mRNA