PHLPP dephosphorylates S473 in AKT Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Matthews, L, 2012-08-03 Pubmed15808505 Pubmed17386267 Reactome Database ID Release 43199425 Reactome, http://www.reactome.org ReactomeREACT_12403 Reviewed: Greene, LA, 2007-11-08 15:39:37 Reviewed: Thorpe, Lauren, 2012-08-13 Reviewed: Yuzugullu, Haluk, 2012-08-13 Reviewed: Zhao, Jean J, 2012-08-13 The PH domain leucine-rich repeat-containing protein phosphatases, PHLPP1 (Gao et al. 2005) and PHLPP2 (Brognard et al. 2007) can specifically dephosphorylate the serine residue and inactivate AKT. p-AKT P-AKT