THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Matthews, L, 2012-08-03 Pubmed11598301 Pubmed12791994 Reactome Database ID Release 43199443 Reactome, http://www.reactome.org ReactomeREACT_12567 Reviewed: Greene, LA, 2007-11-08 15:39:37 Reviewed: Thorpe, Lauren, 2012-08-13 Reviewed: Yuzugullu, Haluk, 2012-08-13 Reviewed: Zhao, Jean J, 2012-08-13 The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003). AKT:PIP3 AKT:PIP3:THEM4/TRIB3 THEM4/TRIB3