Gab1 binds phosphatidylinositol-3,4,5-trisphosphate Authored: Castagnoli, L, 2006-10-10 13:09:34 Edited: Orlic-Milacic, Marija, 2011-08-25 Pubmed10648629 Reactome Database ID Release 43179467 Reactome, http://www.reactome.org ReactomeREACT_12534 Reviewed: Heldin, CH, 2008-02-12 09:44:02 The pleckstrin homology (PH) domain of GAB1 binds to PIP3 and can target GAB1 to the plasma membrane in response to EGF stimulation. This mechanism provides a positive feedback loop with respect to PI3K activation, to enhance EGFR signalling. GRB2:GAB1 GRB2:GAB1:PIP3