Dephosphorylation of Gab1 by SHP2 Authored: Castagnoli, L, 2006-10-10 13:09:34 Phosphorylated GAB1 can bind PI3 kinase by its regulatory alpha subunit. SHP2 dephosphorylation of the tyrosine residues 447, 472 and 589 on GAB1 means PI3 kinase can no longer bind to the complex in the plasma membrane and cannot be activated. Pubmed10734310 Reactome Database ID Release 43177924 Reactome, http://www.reactome.org ReactomeREACT_12605 Reviewed: Heldin, CH, 2008-02-12 09:44:02 has a Stoichiometric coefficient of 3 EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 EGF:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2