GRB2:GAB1:PIK3R1 binds to phosphorylated EGFR Authored: Castagnoli, L, 2006-10-10 13:09:34 Edited: Orlic-Milacic, Marija, 2011-08-25 Pubmed9356464 Reactome Database ID Release 43177941 Reactome, http://www.reactome.org ReactomeREACT_12425 Reviewed: Heldin, CH, 2008-02-12 09:44:02 The regulatory subunit of PIK3 mediates the association of GAB1 and receptor protein-tyrosine kinases such as the EGF receptor, which can phosphorylate GAB1. It appears that the PIK3 regulatory subunit acts as an adaptor protein allowing GAB1 to serve as a substrate for several tyrosine kinases. EGF:p-6Y-EGFR:GRB2:GAB1:PIK3R1 GRB2:GAB1:PIK3R1 EGF:p-6Y-EGFR