AKT phosphorylates GSK3 Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 EC Number: 2.7.11 GSK3 (glycogen synthase kinase-3) participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, and the transcription factors MYB and JUN. GSK3 phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. GSK3 is inhibited when phosphorylated by AKT1. Reactome Database ID Release 43198371 Reactome, http://www.reactome.org ReactomeREACT_12549 Reviewed: Greene, LA, 2007-11-08 15:39:37 GSK3 p-S9/21-GSK3