GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR Authored: Castagnoli, L, 2006-10-10 13:09:34 Edited: Orlic-Milacic, Marija, 2011-08-25 Pubmed8493579 Reactome Database ID Release 43177936 Reactome, http://www.reactome.org ReactomeREACT_12514 Reviewed: Heldin, CH, 2008-02-12 09:44:02 The tyrosine sites on SHC1 become possible binding sites for the GRB2:SOS1 complex. EGF:Phospho-EGFR:Phospho-SHC EGF:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 GRB2:SOS1