Conversion of malonyl-CoA and acetyl-CoA to palmitate Authored: Joshi-Tope, G, 2003-10-23 17:11:00 Cytosolic fatty acid synthase (FAS) complex catalyzes the reaction of acetyl-CoA with 7 malonyl-CoA and 14 NADHP + 14 H+ to form a molecule of palmitate and 7 CO2, 14 NADP+, 8 CoASH, and 6 H2O. The process proceeds via the successive condensations of malonyl groups onto the growing acyl chain,each followed by loss of CO2 and three steps of reduction (Smith et al. 2003). EC Number: 2.3.1.85 Pubmed12689621 Reactome Database ID Release 4375872 Reactome, http://www.reactome.org ReactomeREACT_1497 acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O has a Stoichiometric coefficient of 14 has a Stoichiometric coefficient of 6 has a Stoichiometric coefficient of 7 has a Stoichiometric coefficient of 8