Phosphorylated SHC1 in complex with p-EGFR mutants recruits GRB2:SOS1 complex Authored: Orlic-Milacic, M, 2011-11-04 Edited: D'Eustachio, P, 2011-11-07 Edited: Matthews, L, 2011-11-07 Edited: Wu, G, 2011-11-07 Pubmed15284455 Pubmed8493579 Reactome Database ID Release 431225961 Reactome, http://www.reactome.org ReactomeREACT_115562 Recruitment of GRB2:SOS1 complex by SHC1 bound to phosphorylated dimers of EGFR cancer mutants has not been directly tested, but is assumed to happen in the same way it happens with the SHC1 bound to the phosphorylated homodimer of wild-type EGFR. Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15 GRB2:SOS1 p-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 p-EGFR mutants:p-Y349,350-SHC1