Spontaneous dimerization of ligand-responsive EGFR mutants Authored: Orlic-Milacic, M, 2011-11-04 EGFR ligand-responsive mutants dimerize spontaneously, without ligand binding, although ligand binding ability is preserved. This was experimentally demonstrated for EFGR L858R mutant and is presumed to happen in other constitutively active EGFR kinase domain mutants and EGFR extracellular domain point mutants. Edited: D'Eustachio, P, 2011-11-07 Edited: Matthews, L, 2011-11-07 Edited: Wu, G, 2011-11-07 Pubmed16187797 Pubmed16777603 Pubmed17349580 Pubmed19560417 Reactome Database ID Release 431220614 Reactome, http://www.reactome.org ReactomeREACT_115980 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15 has a Stoichiometric coefficient of 2 Ligand-responsive EGFR mutants dimer Ligand-responsive EGFR mutants:HSP90:CDC37