Disassembly of SR-BI-bound spherical HDL Authored: D'Eustachio, P, 2008-05-12 17:46:52 Edited: D'Eustachio, P, 2008-06-13 14:03:50 Pubmed11561168 Pubmed12788804 Reactome Database ID Release 43349638 Reactome, http://www.reactome.org ReactomeREACT_13762 Reviewed: Jassal, B, 2008-06-13 14:05:49 Spherical HDL particles bound to the cell-surface SR-BI receptor are disassembled, with the release of pre-beta HDL (essentially apoA-I lipoprotein with a few molecules of bound lipid) and the cellular uptake of the bulk of the HDL-associated cholesterol, cholesterol esters, phospholipids, and triacylglycerols. The specificity and efficiency of this process has been demonstrated through a variety of studies in tissue culture model systems (Rigotti et al. 2003; Silver and Tall 2001). The process is annotated here as a concerted event occuring at the cell surface but its molecular details remain incompletely defined and it is possible that the HDL particle is internalized while undergoing disassembly. has a Stoichiometric coefficient of 134 has a Stoichiometric coefficient of 156 has a Stoichiometric coefficient of 2 has a Stoichiometric coefficient of 20 has a Stoichiometric coefficient of 38 spherical HDL:SR-BI complex pre-beta HDL