LDL CETP-mediated lipid exchange: LDL gains cholesterol ester Authored: D'Eustachio, P, 2008-06-13 14:03:50 CETP (cholesterol ester transfer protein) complexed with cholesterol esters interacts with an LDL (low density lipoprotein) particle, acquiring triacylglycerol molecules and donating cholesterol ester to the LDL (Swenson et al. 1988; Morton and Zilversmit 1983). This process is reversible but in the body proceeds in the direction annotated here. A model for the lipid exchange process has been proposed based on recent studies of the structure of CETP:lipid complexes (Qiu et al. 2007). CETP:cholesterol ester complex + LDL <=> LDL:cholesterol ester complex + CETP:triacylglycerol complex Edited: D'Eustachio, P, 2008-06-13 14:03:50 Pubmed17237796 Pubmed2833496 Pubmed6619141 Reactome Database ID Release 43266350 Reactome, http://www.reactome.org ReactomeREACT_13690 Reviewed: Jassal, B, 2008-06-13 14:05:49 LDL:cholesterol ester complex CETP:cholesterol ester complex CETP:triacylglycerol complex