apoA-I binds to CUBN:AMN Authored: D'Eustachio, P, 2008-05-12 17:46:52 Edited: D'Eustachio, P, 2008-06-13 14:03:50 Extracellular apoA-I protein binds to the CUBN (cubilin) subunit of the CUBN:AMN complex associated with the plasma membrane. In the body, this complex is found on the apical surfaces of kidney glomerular cells, where it mediates binding and endocytosis of proteins in the glomerular filtrate, and on the apical surfaces of enterocytes, where it mediates uptake of several vitamins complexed with carrier proteins (notably vitamin B12 (cobalamin):intrinsic factor) (Kozyraki et al. 1999; Fyfe et al. 2004). Pubmed10371504 Pubmed17652309 Reactome Database ID Release 43264848 Reactome, http://www.reactome.org ReactomeREACT_13688 Reviewed: Jassal, B, 2008-06-13 14:05:49 apoA-I:CUBN:AMN complex CUBN:AMN complex