Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants Authored: Orlic-Milacic, M, 2011-11-04 EC Number: 2.7.10 EGFR L858R mutant was shown to directly phosphorylate CBL on tyrosine residue Y371. Other EGFR cancer mutants with phosphorylation of tyrosine Y1045 (Y1069) are assumed to bind and phosphorylate CBL in a manner similar to the wild-type EGFR. Edited: D'Eustachio, P, 2011-11-07 Edited: Gillespie, ME, 2011-11-07 Edited: Matthews, L, 2011-11-07 Edited: Wu, G, 2011-11-07 Pubmed16849543 Reactome Database ID Release 431225960 Reactome, http://www.reactome.org ReactomeREACT_115796 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15 has a Stoichiometric coefficient of 2 Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL Ligand-responsive p-6Y-EGFR mutants:CBL