p-EGFR mutants dimer Dissociation of phosphorylated PLC-gamma 1 from p-EGFR mutants Authored: Orlic-Milacic, M, 2011-11-04 Edited: D'Eustachio, P, 2011-11-07 Edited: Matthews, L, 2011-11-07 Edited: Wu, G, 2011-11-07 Once phosphorylated, PLC-gamma 1 is expected to dissociate from phosphorylated EGFR cancer mutants and induce downstream signaling in the same way it does when activated by the wild-type EGFR. However, except for the phosphorylation of PLCG1 binding site in EGFR cancer mutants, other events involved in activation of PLCG1 signaling have not been studied in cells expressing EGFR cancer mutants. Pubmed15284455 Reactome Database ID Release 431247842 Reactome, http://www.reactome.org ReactomeREACT_115903 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15 p-EGFR mutants:p-Y472,771,783,1254-PLCG1