Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and p-EGFR mutants Authored: Orlic-Milacic, M, 2011-11-04 Edited: D'Eustachio, P, 2011-11-07 Edited: Matthews, L, 2011-11-07 Edited: Wu, G, 2011-11-07 Pubmed15284455 Reactome Database ID Release 431226012 Reactome, http://www.reactome.org ReactomeREACT_116004 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15 The 110 kDa catalytic subunit of PI3K (PIK3CA) binds to the 85 kDa regulatory subunit of PI3K (PIK3R1) to create the active PI3K. EGFR cancer mutants are assumed to mediate the assembly of active PI3K in a manner similar to wild-type EGFR. p-EGFR mutants:GRB2:GAB1:PI3K p-EGFR mutants:GRB2:GAB1:PIK3R1