Beta-Pix pushes CIN85 away from CBL Authored: Castagnoli, L, 2006-10-10 13:09:34 Edited: Orlic-Milacic, Marija, 2011-08-25 High concentrations of active CDC42 and Beta-Pix may promote the binding of Beta-Pix to CBL, pushing out the usually preferred binding partner CIN85 from the CBL complex. This competitive mechanism could block the CIN85-imposed clustering phenomenon on CBL that is required for tighter binding. Pubmed16407834 Reactome Database ID Release 43183002 Reactome, http://www.reactome.org ReactomeREACT_12412 Reviewed: Heldin, CH, 2008-02-12 09:44:02 has a Stoichiometric coefficient of 2 EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP EGF:p-6Y-EGFR:CBL:CIN85 Beta-Pix:CDC42:GTP