Ubiquitination of stimulated EGFR (CBL:GRB2) Authored: Castagnoli, L, 2006-10-10 13:09:34 CBL down-regulates receptor tyrosine kinases by conjugating ubiquitin to them. This leads to receptor internalization and degradation. The ubiquitin protein ligase activity of CBL (abbreviated as E3 activity) is mediated by its RING finger domain. EC Number: 6.3.2.19 Edited: Orlic-Milacic, Marija, 2011-08-25 Pubmed10514377 Pubmed15021893 Reactome Database ID Release 43183036 Reactome, http://www.reactome.org ReactomeREACT_12562 Reviewed: Heldin, CH, 2008-02-12 09:44:02 has a Stoichiometric coefficient of 2 EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 EGF:p-6Y-EGFR:p-Y371-CBL:GRB2 ubiquitin