chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex Authored: D'Eustachio, P, 2007-04-30 14:19:38 Chylomicron micron remnants containing apolipoprotein E associate with the surfaces of cells in a process that probably involves several steps and that requires the presence (but not the catalytic activity) of heparan sulfate proteoglycan (HSPG)-associated hepatic lipase (HL). This process ultimately results in binding of the remnant to cell-surface LDL receptors (LDLR) (Ji et al. 1994). The molecular details of LDLR binding, and of the following steps of remnant endocytosis, are inferred from those of the coorresponding step of LDLR-mediated low-density lipoprotein (LDL) endocytosis. In the body, this process occurs in the liver. Edited: D'Eustachio, P, 2006-02-20 18:35:05 GENE ONTOLOGYGO:0006898 Pubmed8300609 Reactome Database ID Release 43174657 Reactome, http://www.reactome.org ReactomeREACT_6849 chylomicron remnant:apoE:LDLR complex chylomicron remnant:apoE complex