Conversion of pro-apoA-I to apoA-I Authored: D'Eustachio, P, 2008-05-12 17:46:52 EC Number: 3.4.24 Edited: D'Eustachio, P, 2008-06-13 14:03:50 Pubmed16548525 Pubmed17071617 Pubmed17580958 Reactome Database ID Release 43264758 Reactome, http://www.reactome.org ReactomeREACT_13407 Reviewed: Jassal, B, 2008-06-13 14:05:49 The six aminoterminal residues of pro-apolipoprotein A-1 are removed to generate the mature, lipid-binding form of the protein. Studies of tissue culture systems suggest that BMP1 catalyzes this reaction (Chau et al. 2006, 2007). While BMP1 is annotated here as a monomer, its subunit structure is not known, and its 1:1 association with Zn++ is inferred from its sequence similarity to known metallopeptidases. Alpha2-macroglobulin at concentrations found in plasma in inflammatory responses inhibits this reaction in vitro, suggesting a possible link between inflammation and perturbation of HDL function (Zhang et al. 2006; Chau et al. 2007).