Sprouty sequesters CBL away from active EGFR Authored: Castagnoli, L, 2006-10-10 13:09:34 Edited: Orlic-Milacic, Marija, 2011-08-25 Pubmed15962011 Reactome Database ID Release 43182990 Reactome, http://www.reactome.org ReactomeREACT_12387 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Sprouty can constitutively interact with two SH3 domains of CIN85 whereas the third SH3 domain of CIN85 can still associate with CBL on cell activation with EGF. This allows Sprouty to block CIN85-mediated clustering of CBL molecules, stablization of CBL-EGFR interactions and efficient ubiquitination and down-regulation of EGFR. EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15R:Eps15 EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15R:Eps15 SPRY1/2