EGFR non-clathrin mediated endocytosis At higher concentrations of ligand, a substantial fraction of the receptor (>50%) is endocytosed through a clathrin independent, lipid-raft-dependent route as the receptor becomes Y1045 phosphorylated and ubiquitnated. Eps15 and Epsin are found in caveolae. Eps15 and Epsin are immunoprecipated with the EGF receptor. Non-clathrin internalization of ubiquitinated EGFR depends on its interaction with proteins harbouring the UIM Ub-interacting motif, as shown through the ablation of three Ub-interacting motif-containing proteins, Eps15, Eps15R and Epsin. Authored: Castagnoli, L, 2006-10-10 13:09:34 Pubmed12072436 Pubmed15701692 Reactome Database ID Release 43183072 Reactome, http://www.reactome.org ReactomeREACT_12527 Reviewed: Heldin, CH, 2008-02-12 09:44:02 EGF:p-6Y-EGFR:p-Y371-CBL Eps15:HGS:STAM EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15R:Eps15 CIN85:Endophilin