The 5-HT3 receptor complex is permeable to Na+,K+, and Ca2+ when it binds serotonin (5-HT) Authored: Jassal, B, 2010-09-23 Edited: Jassal, B, 2010-09-23 Pubmed17392525 Pubmed7565620 Pubmed9950429 Reactome Database ID Release 43975311 Reactome, http://www.reactome.org ReactomeREACT_25246 Reviewed: He, L, 2010-11-15 The 5-hydroxytryptamine receptor (5-HT3) family are members of the superfamily of LGICs. Five receptors (5-HT3A-E) form a heteropentamer. Binding of the neurotransmitter 5-hydroxytryptamine (serotonin) to the 5-HT3 receptor complex opens the channel, which, in turn, leads to an excitatory response in neurons and is permeable to sodium, potassium, and calcium ions (Miyake et al, 1995; Davies et al, 1999; Niesler et al, 2007).