Calcium is sequestered to the golgi by secretory pathway calcium-ATPases (SPCAs) Accumulation of calcium into the Golgi apparatus is mediated by sarco(endo)plasmic reticulum calcium-ATPases (SERCAs) and by secretory pathway calcium-ATPases (SPCAs). There are two human genes which encode SPCAs; ATP2C1 and ATP2C2 which encode magnesium-dependent calcium-transporting ATPase type 2C members 1 and 2 (ATP2C1 and 2) respectively (Sudbrak et al, 2000; Vanoevelen et al, 2005). Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD), an autosomal dominant disease characterized by persistent blisters and erosions of the skin (Hu et al, 2000). Authored: Jassal, B, 2010-08-24 EC Number: 3.6.3.8 Edited: Jassal, B, 2010-08-24 Pubmed10615129 Pubmed10767338 Pubmed15831496 Reactome Database ID Release 43936883 Reactome, http://www.reactome.org ReactomeREACT_25301 Reviewed: He, L, 2010-11-15