Calcineurin:Phosphorylated NFATC1/2/3 Calcineurin Dephosphorylates NFATC1/2/3 As inferred from mouse (Okamura et al. 2000), calcineurin dephosphorylates NFATC2 at 13 serine residues (Batiuk et al. 1997, Kim et al. 2000). B lymphocytes also contain NFATC2 and NFATC3 which are inferred to undergo dephosphorylation at homologous serines. Dephosphorylation of NFATs exposes a nuclear localization signal which cause NFATs to be imported into the nucleus (Kim et al. 2000). In mouse, Calcineurin is observed to also transit into the nucleus in a complex with NFATs and may remain associated (Shibasaki et al. 1996). Authored: May, B, 2011-12-11 Edited: May, B, 2011-12-11 Pubmed11030334 Pubmed11231878 Pubmed7657645 Pubmed8684469 Pubmed9106655 Pubmed9312192 Reactome Database ID Release 432025882 Reactome, http://www.reactome.org ReactomeREACT_118664 Reviewed: Wienands, J, 2012-02-11 Dephosphorylated NFATC1/2/3