Uchl5 deubiquitinates TGFBR1 Authored: Orlic-Milacic, M, 2012-04-04 EC Number: 3.1.2.15 Edited: Jassal, B, 2012-04-10 Pubmed16027725 Reactome Database ID Release 432179313 Reactome, http://www.reactome.org ReactomeREACT_120821 Recombinant mouse Uchl5 (Uch37) exogenously expressed in HEK293 cells deubiquitinates recombinant human TGFBR1. This stabilizes TGFBR1 and prolongs signaling by TGF-beta receptor complex. Deubiqutination of Smad7 has not been examined in this context (Wicks et al. 2005). Reviewed: Huang, Tao, 2012-05-14 ubiquitin TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-Smad7:Uchl5 TGFB1:p-TGFBR:Ub-Smad7