Formation of Meiotic Holliday Junction Authored: May, B, 2010-07-02 Edited: May, B, 2010-07-02 Formation of Meiotic Recombination Intermediate Pubmed10029069 Pubmed10728666 Pubmed10734115 Pubmed15304223 Pubmed16123081 Pubmed17977839 Reactome Database ID Release 43912496 Reactome, http://www.reactome.org ReactomeREACT_27234 Reviewed: Bolcun-Filas, E, 2011-02-25 Reviewed: Cohen, PE, 2011-02-04 Reviewed: Holloway, JK, 2011-02-04 Reviewed: Lyndaker, A, 2011-02-25 Reviewed: Schimenti, JC, 2011-02-04 Reviewed: Strong, E, 2011-02-25 The 3' end of the invading strand is extended by an unknown DNA polymerase and the extended strand is then ligated back to the original homolog, generating a double Holliday junction. MSH4 and MSH5 form heterodimers which bind Holliday junctions and, in the presence of ATP, slide along the parental duplexes (Bocker et al. 1999, Snowden et al. 2004, Snowden et al. 2008). MSH4 is present at hundreds of meiotic nodules during late zygotene but only about 10% of these nodules become crossovers (Oliver-Bonet et al. 2005). Bloom Syndrome protein (BLM) and Topoisomerase IIIa (TOP3A) are also present and may promote homologous recombination repair without crossing over (Johnson et al. 2000, Wu et al. 2000). Meiotic D-loop Complex Meiotic Holliday Junction