SLCO4C1 mediates the transport of digoxin Authored: Jassal, B, 2010-06-18 Digoxin is a commonly prescribed drug for the treatment of heart failure. It is mainly eliminated from the body by the kidneys. Human SLCO4C1 (formerly OATP-H) is the first member of the organic anion transporting polypeptide (OATP) family expressed in human kidney. It is found on the baolateral membrane of the nephron and is thought to be the first step of the transport of digoxin into urine (Mikkaichi T et al, 2004). Edited: Jassal, B, 2010-06-18 Pubmed14993604 Reactome Database ID Release 43879594 Reactome, http://www.reactome.org ReactomeREACT_23909 Reviewed: He, L, 2010-07-07