AT1 transports acetyl-CoA into the Golgi lumen Authored: Jassal, B, 2010-05-12 Edited: Jassal, B, 2010-05-12 Pubmed19061983 Pubmed9096318 Reactome Database ID Release 43727759 Reactome, http://www.reactome.org ReactomeREACT_22226 Reviewed: He, L, 2010-05-10 The human gene SLC33A1 encodes acetyl-CoA transporter AT1 (Kanamori A et al, 1997).Acetyl-CoA is transported to the lumen of the Golgi apparatus, where it serves as the substrate of acetyltransferases that modify the sialyl residues of gangliosides and glycoproteins. Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42) which is a neurodegenerative disorder (Lin P et al, 2008).