PEX-19 docks ABCD1/D2/D3 to peroximal membrane Authored: Gopinathrao, G, 2008-11-23 14:00:06 Edited: Gopinathrao, G, 2008-11-23 16:45:13 PEX19 is a chaperone protein that binds a broad spectrum of peroxisomal membrane proteins (PMPs), and interacts with regions of PMPs required for their targeting to peroxisomes. PEX3 is required for PEX19 to dock at peroxisomes, interacts specifically with the docking domain of PEX19, and is required for recruitment of the PEX19 docking domain to peroxisomes. The ABC transporters D1, D2 and D3 must first form dimers to become fully functional (Liu et al.1999) which then can bind with PEX19. Pubmed10551832 Pubmed10704444 Pubmed10777694 Pubmed15007061 Pubmed9345306 Reactome Database ID Release 43382613 Reactome, http://www.reactome.org ReactomeREACT_15396 Reviewed: Matthews, L, 2008-12-02 15:41:53 PEX19 ABCD1/2/3 dimers PEX19:ABCD1/2/3