Na+, K+/2Cl- cotransport Authored: Jassal, B, 2009-06-12 Edited: Jassal, B, 2009-06-12 Pubmed7629105 Pubmed8640224 Reactome Database ID Release 43426086 Reactome, http://www.reactome.org ReactomeREACT_19223 Reviewed: He, L, 2009-08-24 Two genes (SLC12A1 and SLC12A2) encode Na+,K+/2Cl- cotransporters (NKCC2 and NKCC1 respectively). SLC12A1 (Simon DB et al, 1996) is kidney-specific whilst SLC12A2 (Payne JA et al, 1995) is ubiquitously expressed. Two Cl- ions are electroneutrally transported into cells with a Na+ ion and a K+ ion. has a Stoichiometric coefficient of 2