K+-dependent Na+/Ca2+ exchanger transport Authored: Jassal, B, 2009-06-05 Edited: Jassal, B, 2009-06-05 Pubmed10662833 Pubmed11294880 Pubmed12379639 Pubmed16357253 Pubmed9856482 Reactome Database ID Release 43425678 Reactome, http://www.reactome.org ReactomeREACT_19339 Reviewed: He, L, 2009-08-24 The five members of the NCKX (SLC24) family are all able to exchange one Ca2+ and one K+ for four Na+. They play a major role in the phototransduction cascade by controlling the Ca2+ concentration of the outer segments of retinal rod and cone cells during light and dark conditions. NCKX1 (SLC24A1) encodes an exchanger protein which is the most extensively studied member (Tucker JE et al, 1998). It is highly expressed in the eye. Other members are expressed in the brain and skin as well as the eye (Prinsen CF et al, 2000; Kraev A et al, 2001; Li XF et al, 2002; Lamason RL et al, 2005). has a Stoichiometric coefficient of 4