compounds transported by GLUT9 compounds transported by GLUT9 GLUT9 transports glucose, fructose and urate Authored: Jassal, B, 2009-07-14 Edited: Jassal, B, 2009-07-14 Pubmed10860667 Pubmed14739288 Pubmed18327257 Reactome Database ID Release 43429036 Reactome, http://www.reactome.org ReactomeREACT_19288 Reviewed: He, L, 2009-08-24 The human SLC2A9 gene encodes two isoforms of class II facilitative glucose transporter 9; GLUT9 (Phay JE et al, 2000) and GLUT9DeltaN (Augustin R et al, 2004). GLUT9 is expressed mainly in kidney (proximal tubules of epithelial cells) and liver while GLUT9DeltaN is expressed mainly in kidney and placenta. As well as mediating the uptake of fructose and glucose (at a low rate), GLUT9 can also mediate the tranpsort of urate (uric acid), the end product of purine metabolism in humans and great apes (Vitart V et al, 2008). Mutations in SLC2A9 influence serum urate concentrations with excess serum accumulation of urate leading to the development of gout (Vitart V et al, 2008).