Group 1 - Sulphate transport Authored: Jassal, B, 2009-06-23 Edited: Jassal, B, 2009-06-23 Pubmed12713736 Pubmed7923357 Reactome Database ID Release 43427555 Reactome, http://www.reactome.org ReactomeREACT_19330 Reviewed: He, L, 2009-08-24 The SLC26A1 and 2 genes encode proteins that facilitate sulfate uptake into cells. The mechanism by which these transporters work is unclear but may be enhanced by extracellular halides or acidic pH environments, cotransporting protons electroneutrally. SLC26A1 encodes the sulfate anion transporter 1 (SAT1) (Regeer RR et al, 2003) which can transport sulfate and oxalate across the basolateral membrane of epithelial cells. It is most abundantly expressed in the liver and kidney, with lower levels expressed in many other parts of the body.<br.><br>SLC26A2 is ubiquitously expressed and encodes a sulfate transporter (Diastrophic dysplasia protein, DTD, DTDST) (Hastbacka J et al, 1994). This transporter provides sulfate for proteoglycan sulfation which is needed for cartilage development. Defects in SLC26A2 are implicated in the pathogenesis of several human chondrodysplasias. has a Stoichiometric coefficient of 2