Co-transport (influx) of glucose and Na+ ions by SGLT2 Authored: Jassal, B, 2009-07-17 Edited: Jassal, B, 2009-07-17 Pubmed1415574 Pubmed14614622 Reactome Database ID Release 43429613 Reactome, http://www.reactome.org ReactomeREACT_19399 Reviewed: He, L, 2009-08-24 The human gene SLC5A2 encodes a sodium-dependent glucose transporter, SGLT2 (Wells RG et al, 1992). SGLT2 is expressed in many tissues but primarily in the kidney, specifically the renal proximal tubules (S1 and S2 segments).It is a low affinity, high capacity transporter of glucose across the apical membrane, with co-transport of Na+ ions in a 1:1 ratio. Unlike SGLT1, it doesn't transport galactose. SGLT2 is the main transporter of glucose in the kidney, responsible for approximately 98% of glucose reabsorption (reaminder by SGLT1). Defects in SLC5A2 are the cause of renal glucosuria (GLYS1), an autosomal recessive renal tubular disorder (Calado J et al, 2004).