ZIP7 mediates zinc efflux from the endoplasmic reticulum Authored: Jassal, B, 2009-09-25 Edited: Jassal, B, 2009-08-21 Pubmed14525538 Reactome Database ID Release 43442393 Reactome, http://www.reactome.org ReactomeREACT_20575 Reviewed: He, L, 2009-11-12 The human gene SLC39A7 encodes the zinc transporter ZIP7 (HKE4, Histidine-rich membrane protein Ke4). It is expressed in many tissues but especially in liver, kidney and the hormonal tissues apart from brain. Unlike the other members of the LZT subfamily, ZIP7 is localized to intracellular membranes of the ER rather than the plasma membrane and mediates zinc efflux into the cytoplasm (Taylor KM et al, 2004).