Biogenic amines transported by VMAT1/2 Biogenic amines transported by VMAT1/2 VMAT1/2 can mediate the transport of biogenic amines Authored: Jassal, B, 2009-10-22 Edited: Jassal, B, 2009-08-21 Pubmed8245983 Pubmed8643547 Reactome Database ID Release 43444160 Reactome, http://www.reactome.org ReactomeREACT_20519 Reviewed: He, L, 2009-11-12 The human gene SLC18A1 encodes the vesicular monoamine transporter 1 (VMAT1) (Erickson JD et al, 1996). VMAT1 is mainly expressed in neuroendocrine cells. The human gene SLC18A2 encodes VMAT2 (Erickson JD and Eiden LE, 1993). Both transporters can mediate the transport of biogenic amines into secretory vesicles, which can then discharge their contents into the extracellular space by exocytosis. Predominant biogenic amines these proteins can transport are serotonin, dopamine, adrenaline, noradrenaline and histamine.