Interaction of DAP12 and SIRP beta Authored: Garapati, P V, 2009-02-12 18:17:40 Edited: Garapati, P V, 2009-02-12 18:17:40 Pubmed10604985 Pubmed10940905 Pubmed16691243 Reactome Database ID Release 43210274 Reactome, http://www.reactome.org ReactomeREACT_23798 Reviewed: Barclay, AN, 2010-05-20 SIRP beta , also named CD172b, is expressed mainly on myeloid cells and has a very short cytoplasmic region of only six amino acids, lacking the signaling motifs for association with phosphatases that are found in the highly related SIRP alpha receptor. Instead, SIRP associates with a dimeric protein DAP12 to transmit activating signals via an ITAM in the cytoplasmic domain of DAP12. A positively charged amino acid in the transmembrane domain of DAP12 associate with a basic amino acid in SIRP beta's transmembrane region. SIRP beta1:DAP12